What is lactobacillus rhamnosus

To date, regarding the use of LGG in the oncology practice, there are no studies showing the onset of complications due to the administration of probiotics. With particular reference to oncologic pathologies, only two cases of bacteremia have been reported following the administration of probiotics. Both patients had onco-hematologic tumors and in both cases the development of bacteremia was attributable not to tumor but to bone marrow transplantation and to immunosuppressive therapies performed by patients Majcher-Peszynska et al.

These data show that the use of LGG in support of cancer therapy has a high level of safety, although very rarely were recorded episodes of bacteremia.

Redman et al. The authors analyzed 17 studies, including people probiotics administered, not consuming probiotics. The overlook for safety has been conducted considering different probiotics such as Saccharomyces boulardii , several species of Lactobacillus including LGG and Bifidobacterium together with Streptococcus thermophilus and VLS 3 a multispecies formula.

Only rare AEs relate to probiotics administration were described but none of them was associated with the use of LGG even during neutropenia caused by chemotherapy Redman et al. Decades of clinical practice have experienced the use of probiotics as food supplies that can help patients, most likely affected by intestinal dysbiosis or by concomitant diseases.

Since the time it was isolated, LGG has proven to be effective, through in vitro and in vivo experiments against inflammation, epithelial damage, invasiveness and proliferation of malignancies. Several studies on humans have been conducted to assess its usefulness against AE such diarrhea experienced by cancer patients. Even though the lack of studies homogeneity, the administration of LGG is clearly safe.

Well-designed clinical trials are mandatory to define the appropriate use of LGG during anti-cancer treatments, including pelvic radiation therapy and chemotherapy. According to the results obtained by such clinical trials, LGG may be regulated based on their use. We are confident that LGG may exert an important role in preserving the gut microbiota during such treatments and in improving the quality of life. Such positive effects of LGG administration may also enhance the adherence and compliance to treatments.

MS contributed to discuss the characterization of LGG. The manuscript was amended based on comments from all authors. All authors read and approved the final version of the manuscript. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Andreyev, H. Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer.

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Proteome Res. Krautkramer, K. Diet-microbiota interactions mediate global epigenetic programming in multiple host tissues. Cell 64, — Land, M. Lactobacillus sepsis associated with probiotic therapy. Medicinal use of this product has not been approved by the FDA. Lactobacillus rhamnosus GG should not be used in place of medication prescribed for you by your doctor.

Lactobacillus rhamnosus GG is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs.

Before using lactobacillus rhamnosus GG, talk to your healthcare provider. You may not be able to use lactobacillus rhamnosus GG if you have certain medical conditions, especially:. When considering the use of herbal supplements, seek the advice of your doctor. If you choose to take lactobacillus rhamnosus GG, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider.

Do not use more of this product than is recommended on the label. If you cannot swallow a capsule whole, open the capsule and sprinkle the medicine into a spoonful of a baby food or applesauce to make swallowing easier. Swallow right away. Do not save the mixture for later use.

Discard the empty capsule. If you take lactobacillus rhamnosus GG to prevent traveler's diarrhea, start taking it 2 or 3 days before you travel.

Keep taking it daily throughout the trip. Call your doctor if the condition you are treating with lactobacillus rhamnosus GG does not improve, or if it gets worse while using this product.

Lactobacillus rhamnosus GG is available in capsule form. Other forms may also be available. Some dairy products, especially yogurt, also contain lactobacillus rhamnosus GG. Do not use many different forms of lactobacillus rhamnosus GG at the same time, unless your healthcare provider has told you to.

You may get too much of this product if you use different forms together. Store at room temperature away from moisture, heat, and sunlight. Keep each capsule in its foil blister pack until you are ready to take the product. Skip the missed dose if it is almost time for your next scheduled dose.

Do not use extra lactobacillus rhamnosus GG to make up the missed dose. Avoid taking lactobacillus rhamnosus GG within 2 hours before or after you take any medicine, especially an antibiotic. Some antibiotics can make lactobacillus rhamnosus GG less effective. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, lactobacillus rhamnosus GG is thought to be likely safe for most people when used as directed. Research Studies. Get Involved. Cancer Biology Research. Cancer Genomics Research. Research on Causes of Cancer. Cancer Prevention Research. Cancer Treatment Research.

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